Post-conditioning with gradually increased reperfusion provides better cardioprotection in rats

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An improved postconditioning algorithm: gradually increased reperfusion provides improved cardioprotection in rats.

The aim of the present study was to investigate whether a gradually increasing reperfusion algorithm, in which the brief reperfusion was lengthened as the duration of each reperfusion/reocclusion cycle remained fixed, enhances cardioprotection. Rats were randomized into 5 groups: the sham, reperfusion injury (R/I), gradually decreased reperfusion (GDR; 30/10‑25/15‑15/25‑10/30 sec of reperfusion...

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Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities

In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

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ژورنال

عنوان ژورنال: World Journal of Emergency Medicine

سال: 2014

ISSN: 1920-8642

DOI: 10.5847/wjem.j.issn.1920-8642.2014.02.009